Treating A Migraine With A Simple Puff Of Air

Treating A Migraine With A Simple Puff Of Air

John Nosta 22/07/2018 4

A headache, particularly a migraine, can be a stifling condition. In fact, migraine is the third most common disease in the world and more prevalent than diabetes, epilepsy and asthma combined.

Another headache is drug therapy itself. Drugs such as triptans account for more than 90% of prescribed therapies. However, patients routinely report dissatisfaction due to low effectiveness and common side effects such as nausea, drowsiness, skin reactions, and actual worsening of headache. New investigational drugs offer some hope, but they are not without concerns. These therapies, such as erenumab and atogepant, are among a new class of migraine drugs targeting a protein associated with the pain-signaling peptide CGRP. However, these are injectables with high price tags. The problematic (and overprescribed) role of opioids for migraine, concerns around the hepatic toxicity of acetaminophen, and CV and gastrointestinal side effects of NSAIDS, all make conventional pharmacotherapy a complicated clinical course to navigate—for both the clinician and patient.

A new, medication-free option in development from Nocira may offer relief from migraines in an amazingly simple, yet effective way: a puff of air.


The device is a small pocket-sized pump connected by a thin tube to earpieces, similar to in-ear audio earbuds. A mobile phone app controls the system to deliver a precise pattern of low-pressure air pulses to the external ear canal. The controlled "puffs of air" or pressure modulation stimulate mild nerve impulses. It's postulated that this activity resets the overactive pain-generating areas in brain. This noninvasive therapy is administered for up to 30 minutes, with most patients achieving complete or significant relief in less than half that time, according to published pilot study data. An added benefit is that many patients have remarked that the therapy is soothing and comforting—an interesting observation that might indicate the potential for expanded use in conditions such as vertigo and nausea.

The unique treatment mechanism can be used anywhere, at any time, for patients feeling onset symptoms of a migraine. There are no other treatments with the convenience of a mobile application to help patients self-treat. And, since this mechanism can be carried with you anywhere you go, it offers a level of convenience that is incomparable to any other migraine therapy on the market today. What’s more is that the mobile technology is personalized to each patient, providing smart learning and adaptations to therapies to supporting individual preferences, so that over time a patient’s treatment can be modified and improved, as well as the ability to include added therapies.

The initial data are impressive, yet the sample size is small. In one study with 30 migraine subjects, 67% achieved complete pain resolution, all within a 2-hour post-treatment period. Additionally, subjects reported a consistently overall favorable and comfortable experience. The company hopes to confirm these findings in a more significant study in the near future for pre-market review by the FDA.

In a market that can be defined by high patient dissatisfaction, it's nice to have a technological innovation that's simple and easy—almost like using a smartphone to treat a migraine. And that can be a big, patient-empowering step forward.  From a simple consumer device to the potential to avoid medication, Nocira's approach may offer new hope for patients who have been searching without resolve for a long time.

Follow me @JohnNosta for a more informed and healthy future.

A version of this article first appeared on Forbes.

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  • Robin Nelson

    While Nocira could be recommended to all patients with a migraine diagnosis, the cost of the device is likely to make it a better choice for people whose frequent attacks are not responsive to other acute therapies.

  • Laura Griffiths

    I hate migraines, they are so painful....

  • Thomas Perera

    If this device can sort out once and for all my frequent migraines, then I wanna buy it.

  • Emily Rowlands

    This is so simple to use

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John Nosta

Digital Health Expert

John is the #1 global influencer in digital health and generally regarded as one of the top global strategic and creative thinkers in this important and expanding area. He is also one the most popular speakers around the globe presenting his vibrant and insightful perspective on the future of health innovation. His focus is on guiding companies, NGOs, and governments through the dynamics of exponential change in the health / tech marketplaces. He is also a member of the Google Health Advisory Board, pens HEALTH CRITICAL for Forbes--a top global blog on health & technology and THE DIGITAL SELF for Psychology Today—a leading blog focused on the digital transformation of humanity. He is also on the faculty of Exponential Medicine. John has an established reputation as a vocal advocate for strategic thinking and creativity. He has built his career on the “science of advertising,” a process where strategy and creativity work together for superior marketing. He has also been recognized for his ability to translate difficult medical and scientific concepts into material that can be more easily communicated to consumers, clinicians and scientists. Additionally, John has distinguished himself as a scientific thinker. Earlier in his career, John was a research associate at Harvard Medical School and has co-authored several papers with global thought-leaders in the field of cardiovascular physiology with a focus on acute myocardial infarction, ventricular arrhythmias and sudden cardiac death.

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